• Introduction Breast cancer is the most common type of cancer

  2019-08-11

  

  Introduction Breast cancer is the most common type of cancer in women, accounting for 28% of total cancer cases across Europe [1]. In 2014, 92,500 women died from breast cancer in the EU-28 [2]. Through better diagnostic techniques and advancement in surgical and pharmacological treatment, mortali

• It is generally accepted that angiogenesis

  2019-07-30

  

  It is generally accepted that angiogenesis is a fundamental step in the transition of tumors from a benign state to a malignant one [28]. Therefore, targeting the angiogenic pathway has become a choice therapeutic strategy for advanced CRC [29]. Interestingly, we observed that overexpressed CCR6 enh

• br Conclusions and future directions of research NASH relate

  2019-07-30

  

  Conclusions and future directions of research NASH-related cirrhotic patients receive significantly less surveillance for HCC than those with HCV-related cirrhosis [98]. As a matter of fact, this is strongly in Tadalafil with epidemiological data and represents a considerable problem of public he

• Introduction Chronic cardiomyopathy is the most frequent and

  2019-07-24

  

  Introduction Chronic cardiomyopathy is the most frequent and severe manifestation of Chagas disease, triggered by infection with the protozoan parasite Trypanosoma cruzi. It affects approximately one-third of T. cruzi-infected patients, typically years or decades after the initial exposure [1]. Mul

• In this study we stably transfected the highly invasive

  2019-07-24

  

  In this study, we stably transfected the highly invasive, triple-negative (ER-, PR-, HER2-), human breast cancer cell line MDA-MB-231 with wild-type (WT) NHERF1, with NHERF1 mutated from serine to alanine such that they could no longer be phosphorylated in serine 279 (S279A), in serine 301 (S301A) o

• br Materials and methods br Results br Discussion

  2019-07-11

  

  Materials and methods Results Discussion Estrogen is a potent positive regulator of bone mass and its insufficiency elicits unwarranted differentiation and activity of osteoclasts, causing excessive bone resorption and thus leads to increased risk of osteoporosis observed in postmenopausal

• br D culture systems and liver organoids As highlight by

  2019-07-08

  

  3D culture systems and liver organoids As highlight by the magazine The Economist in “The year of the organoid-The World in 2016”, another recent advance of the stem cell technology is the possibility to generate organoids. Organoids are based on the three-dimensional culture systems of stem cell

• BDNF is a neurotrophin widely

  2019-07-08

  

  BDNF is a neurotrophin widely expressed in CNS, mostly present in hippocampus and cerebral cortex. BDNF is involved in neuronal repair, dendritic and axonal growth, long-term potentiation and synaptic plasticity [127], associated with hippocampal volume reduction and memory function in aging process

• The Drosophila model is well

  2019-07-06

  

  The Drosophila model is well-suited to study the effects of exercise on heart function in a controlled manner. Because flies have an innate reaction to climb up in response to a negative geotaxis stimulus, they can easily be subjected to an exercise routine on a large scale [242]. Evidence supports

• br Competing interests br Transparency

  2019-07-05

  

  Competing interests Transparency document Authors' contributions Acknowledgments This work was supported by the Spanish Ministry of Economy and Business through the grant Plan Estatal SAF2017-83372-R (FEDER funds/UE) and MDM-2014-0370 through the “María de Maeztu” Programme for Units of

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