A769662 br Primary tumour volume reduction during EBRT is
Primary tumour volume reduction during EBRT is, and ADC in-crease during EBRT might be, a good predictor for regional and distant control; however their relation is not fully clarified. Perhaps it is the tumour biology of the primary tumours and the lymph node metastasis and their response to treatment that link both outcomes. Therefore, other interventional strategies might be considered for patients with a higher risk of regional or distant recurrence, such as a higher dose to distant lesions which should always be applied with great caution. In conclusion, as for primary tumours in the cervix, ADC values of affected nodes increase during EBRT. ADC values can be obtained from delineated volumes of primary tumour on T2 weighted MR unless there are substantial shifts between ADC mapping and T2 signal. Evaluation of ΔADC for primary tumours and affected lymph nodes might help to better predict response to EBRT and disease outcome. This study is in line with available evidence that volume reduction of the primary cervical tumour during EBRT is a prognostic factor for relapse.
Conflicts of interest
Cornelis van den Berg is a minority share holder of MRCode BV. The other authors declare that there are no conflicts of interest.
Role of funding source
The authors declare that no study sponsors were involved.
We kindly acknowledge Simon Woodings, medical physicist at the Department of Radiation Oncology of the University Medical Centre Utrecht, for his thorough revisions and support.
Appendix A. Supplementary data
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